AGAP2-AS1

Across TCGA pan-cancer cohorts, AGAP2-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of AGAP2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AGAP2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AGAP2-AS1 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where AGAP2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AGAP2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.474	<.001	12	view →
COAD	Male	III,IV	+1.577	<.001	11	view →
KIRC	Male	III,IV	+1.285	<.001	11	view →
STAD	All	II,III,IV	+0.929	<.001	9	view →
READ	All	All	+1.126	<.001	7	view →
LUAD	All	II,III,IV	+0.809	<.001	7	view →
UCEC	All	All	−1.723	<.001	6	view →
LUSC	Female	II,III,IV	+1.531	<.001	6	view →
KICH	Female	All	−1.364	<.001	4	view →
CHOL	All	All	+3.092	<.001	3	view →
KIRP	All	All	+0.706	.006	3	view →
ESCA	All	All	+1.631	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

AGAP2-AS1–HNSC

Open the HNSC breakdown →