AGAP1

Across TCGA cell cohorts, AGAP1 mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGAP1-associated genes across cancer lineages are OR4F4, CYB5D1, and TIFAB. Each is linked with AGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP1-to-partner and partner-to-AGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by AGAP1-low versus AGAP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP1→partner) and Y-score (partner→AGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4F4 →	+0.009	+3.584	<.001	.004	3	2
LARGE_INTESTINE	CYB5D1 →	+1.027	+3.212	.001	.006	3	2
LARGE_INTESTINE	TIFAB →	+0.002	+2.754	<.001	.009	3	2
LUNG_SCLC	MINDY4B →	+1.334	+4.523	.003	.003	3	2
BLOOD_Lymphoma	H1-1 →	+0.104	+3.807	.001	.004	3	1
BLOOD_Leukemia	VSX2 →	+0.029	+3.258	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

OR4F4 by AGAP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →