AGAP1-IT1

Across TCGA pan-cancer cohorts, AGAP1-IT1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated AGAP1-IT1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher AGAP1-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AGAP1-IT1 expression acts as an unfavorable survival marker, although some lineages such as THCA and MESO show a favorable association.

ACC, THCA, and ESCA are the cancer types where AGAP1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.198	0.614	<.001	66	view →
THCA	DFS	Tertile	All	0.910	0.769	.004	64	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	48	view →
MESO	DFS	Quartile	All	0.514	0.322	.011	36	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	36	view →
LIHC	OS	Median	III,IV	0.211	0.493	.001	32	view →
SARC	DFS	Tertile	All	0.473	0.680	<.001	31	view →
UVM	DFS	Quartile	II,III,IV	0.338	0.738	.003	30	view →
LGG	DFS	Tertile	All	0.633	0.810	<.001	29	view →
KIRP	OS	Median	All	0.588	0.890	.003	26	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	25	view →
CESC	DFS	Quartile	All	0.738	0.897	.002	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

AGAP1-IT1–ACC (DFS)

Open the ACC breakdown →