AGAP1-IT1

Across TCGA pan-cancer cohorts, AGAP1-IT1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of AGAP1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AGAP1-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types AGAP1-IT1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and BLCA are the cancer types where AGAP1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AGAP1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−0.888	<.001	11	view →
LUSC	All	III,IV	−1.766	<.001	9	view →
BLCA	All	All	+0.471	<.001	9	view →
HNSC	Male	II,III,IV	+0.323	.001	7	view →
BRCA	All	III,IV	+1.257	<.001	6	view →
LUAD	Female	All	−1.068	<.001	6	view →
UCEC	All	All	+0.372	.011	4	view →
LIHC	Male	All	−1.146	<.001	3	view →
CHOL	Female	All	−2.160	.033	2	view →
PRAD	All	All	+0.588	<.001	2	view →
COAD	All	All	−0.358	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

AGAP1-IT1–KICH

Open the KICH breakdown →