AFP

Across TCGA patient cohorts, AFP mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFP-associated genes across cancer lineages are FASN, EGFR_pY1068, and EGFR. Each is linked with AFP in more than 2 cancer types. Because this analysis shows association rather than direction, both AFP-to-partner and partner-to-AFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by AFP-low versus AFP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFP→partner) and Y-score (partner→AFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.396	+1.736	.003	.007	3	3
UCEC	EGFR_pY1068 →	-0.237	-2.115	.006	.016	3	2
SKCM	EGFR →	-0.149	-2.321	.042	.033	3	2
UCEC	mTOR_pS2448 →	-0.142	-1.440	.006	.024	3	2
UCEC	p53 →	-0.270	-2.999	.044	.035	3	2
UCEC	PDCD4 →	-0.489	-1.736	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

FASN by AFP expression — UCEC

Explore this box plot interactively →