AFP

Across TCGA pan-cancer cohorts, AFP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated AFP data layer compared with 6 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher AFP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AFP expression acts as an unfavorable survival marker, although some lineages such as READ and ACC show a favorable association.

MESO, HNSC, and KIRP are the cancer types where AFP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	II,III,IV	0.232	0.529	.002	61	view →
HNSC	DFS	Tertile	All	0.567	0.815	<.001	57	view →
KIRP	DFS	Quartile	All	0.788	0.939	.001	55	view →
READ	OS	Quartile	All	0.900	0.291	.001	54	view →
LGG	OS	Median	All	0.725	0.874	<.001	48	view →
KICH	OS	Quartile	II,III,IV	0.461	1.000	.001	35	view →
LUAD	OS	Quartile	II,III,IV	0.354	0.611	.002	31	view →
THCA	OS	Tertile	All	0.947	1.000	.005	27	view →
LIHC	OS	Median	II,III,IV	0.534	0.684	.010	26	view →
ACC	DFS	Median	II,III,IV	0.700	0.385	.001	25	view →
LUSC	DFS	Tertile	All	0.810	0.685	.002	24	view →
KIRC	DFS	Tertile	II,III,IV	0.636	0.743	.017	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

AFP–MESO (OS)

Open the MESO breakdown →