AFP

Across TCGA cell cohorts, AFP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,404 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AFP-associated GO terms across cancer lineages are Maintenance of location, Response to oxygen levels, and Endothelial cell morphogenesis. Each is linked with AFP in more than 5 cancer types. Because this analysis shows association rather than direction, both AFP-to-partner and partner-to-AFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of location grouped by AFP-low versus AFP-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFP→partner) and Y-score (partner→AFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Maintenance of location →	+0.058	+0.527	.004	.007	3	6
BONE	Response to oxygen levels →	+0.057	+1.312	<.001	.001	3	6
BLOOD_Leukemia	Endothelial cell morphogenesis →	+0.733	+0.641	<.001	.003	3	6
KIDNEY	Regulation of very-low-density lipoprotein particle remodeling →	+1.254	+1.658	.005	.001	3	6
BONE	Angiogenesis →	+0.102	+1.397	<.001	<.001	3	5
BLOOD_Leukemia	Positive regulation of blood pressure by epinephrine-norepinephrine →	+0.633	+1.251	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,404 associations by consensus.

Maintenance of location by AFP expression — BREAST

Explore this box plot interactively →