AFP

Across TCGA cell cohorts, AFP mutation is significantly associated with the RNA expression of many other genes, with 482 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFP-associated genes across cancer lineages are IL36A, CASP5, and ADGRL4. Each is linked with AFP in more than 1 cancer types. Because this analysis shows association rather than direction, both AFP-to-partner and partner-to-AFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by AFP-low versus AFP-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFP→partner) and Y-score (partner→AFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	CASP5 →	+0.085	+3.898	<.001	.005	3	1
LUNG_SCLC	ADGRL4 →	+0.204	+3.807	<.001	.006	3	1
LUNG_SCLC	OR7G3 →	+0.038	+4.058	<.001	.007	3	1
LUNG_SCLC	OR4S1 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	OR4C6 →	+0.016	+4.169	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 482 associations by consensus.

IL36A by AFP expression — LUNG_SCLC

Explore this box plot interactively →