AFM

Across TCGA patient cohorts, AFM RNA expression is significantly associated with the go_rna of many other GO terms, with 6,231 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible AFM-associated GO terms across cancer lineages are Reverse cholesterol transport, Regulation of very-low-density lipoprotein particle remodeling, and Thioester metabolic process. Each is linked with AFM in more than 6 cancer types. Because this analysis shows association rather than direction, both AFM-to-partner and partner-to-AFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Reverse cholesterol transport grouped by AFM-low versus AFM-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFM→partner) and Y-score (partner→AFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	Reverse cholesterol transport →	+0.090	+3.032	<.001	<.001	3	7
TGCT	Regulation of very-low-density lipoprotein particle remodeling →	+0.555	+0.504	<.001	<.001	3	6
CHOL	Thioester metabolic process →	+0.072	+4.747	<.001	<.001	3	6
TGCT	Thioester biosynthetic process →	+0.030	+0.338	<.001	<.001	3	6
CHOL	Primary alcohol metabolic process →	+0.077	+5.241	<.001	<.001	3	6
CHOL	Branched-chain amino acid metabolic process →	+0.052	+2.698	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,231 associations by consensus.

Reverse cholesterol transport by AFM expression — CHOL

Explore this box plot interactively →