AFM

Across TCGA pan-cancer cohorts, AFM RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of AFM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AFM RNA is repressed in tumor relative to normal tissue. In most cancer types AFM is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where AFM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AFM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−2.652	<.001	12	view →
KIRP	All	III,IV	−4.486	<.001	11	view →
LIHC	Female	All	−2.978	<.001	8	view →
KICH	All	II,III,IV	−3.180	<.001	7	view →
CHOL	Female	All	−8.376	<.001	5	view →
LUAD	All	II,III,IV	+0.031	.001	5	view →
BLCA	All	III,IV	+0.028	.022	5	view →
UCEC	All	All	−0.214	.008	4	view →
PRAD	All	All	−0.021	<.001	2	view →
HNSC	Male	All	+0.018	.008	2	view →
ESCA	All	All	−0.483	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

AFM–KIRC

Open the KIRC breakdown →