AFM

Across TCGA patient cohorts, AFM protein abundance is significantly associated with the RNA expression of many other genes, with 14,549 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AFM-associated genes across cancer lineages are F13A1, IGFBP7, and CD93. Each is linked with AFM in more than 7 cancer types. Because this analysis shows association rather than direction, both AFM-to-partner and partner-to-AFM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AFM versus F13A1 in OV, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFM→partner) and Y-score (partner→AFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	F13A1 →	+1.581	+0.557	<.001	.002	3	8
COAD	IGFBP7 →	+0.845	+0.480	<.001	.003	3	8
GBM	CD93 →	+0.923	+0.649	<.001	<.001	3	8
COAD	CNN1 →	+1.660	+0.500	<.001	<.001	3	7
COAD	AOC3 →	+1.320	+0.538	<.001	<.001	3	7
GBM	LYVE1 →	+1.165	+0.615	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,549 associations by consensus.

AFM vs F13A1 — OV

Explore this scatter interactively →