AFM

Across TCGA patient cohorts, AFM mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFM-associated genes across cancer lineages are Tuberin, Caspase-8, and Notch1. Each is linked with AFM in more than 1 cancer types. Because this analysis shows association rather than direction, both AFM-to-partner and partner-to-AFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by AFM-low versus AFM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFM→partner) and Y-score (partner→AFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.396	+3.807	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.297	-2.459	<.001	<.001	3	2
UCEC	Notch1 →	+0.137	+2.710	.005	.003	3	2
UCEC	Tuberin_pT1462 →	+0.284	+1.687	<.001	.013	3	2
SKCM	p21 →	-0.455	-1.807	.003	.024	3	1
SKCM	PREX1 →	-0.315	-2.000	.008	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Tuberin by AFM expression — UCEC

Explore this box plot interactively →