AFM

Across TCGA cell cohorts, AFM RNA expression is significantly associated with the go_rna of many other GO terms, with 425 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible AFM-associated GO terms across cancer lineages are Vesicle budding from membrane, Vesicle coating, and Cellular response to nitrosative stress. Each is linked with AFM in more than 2 cancer types. Because this analysis shows association rather than direction, both AFM-to-partner and partner-to-AFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle budding from membrane grouped by AFM-low versus AFM-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFM→partner) and Y-score (partner→AFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Vesicle budding from membrane →	+0.037	+0.011	.008	.006	3	3
SKIN	Vesicle coating →	+0.039	+0.007	.008	.007	3	3
SKIN	Cellular response to nitrosative stress →	+0.105	+0.017	<.001	<.001	3	3
CNS	Protein autoubiquitination →	+0.028	+0.011	.006	.001	3	3
CNS	Self proteolysis →	+0.116	+0.011	<.001	.001	3	3
LIVER	Regulation of natural killer cell activation →	-0.144	-0.393	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

Vesicle budding from membrane by AFM expression — SKIN

Explore this box plot interactively →