AFM

Across TCGA cell cohorts, AFM mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible AFM-associated genes across cancer lineages are KRTAP2-4, NEUROD4, and CEACAM3. Each is linked with AFM in more than 1 cancer types. Because this analysis shows association rather than direction, both AFM-to-partner and partner-to-AFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP2-4 grouped by AFM-low versus AFM-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFM→partner) and Y-score (partner→AFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KRTAP2-4 →	+0.049	+4.807	<.001	.006	3	2
BLOOD_Myeloma	NEUROD4 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CEACAM3 →	+0.053	+4.807	<.001	.006	3	1
LUNG_SCLC	CELA1 →	+0.028	+4.058	<.001	.007	3	1
LUNG_SCLC	CFC1B →	+0.228	+3.736	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

KRTAP2-4 by AFM expression — BLOOD_Myeloma

Explore this box plot interactively →