AFF1

Across TCGA pan-cancer cohorts, AFF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AFF1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AFF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated AFF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where AFF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.899	0.557	.022	9	view →
PDAC	DFS	Median	III,IV	0.936	0.426	.008	9	view →
GBM	DFS	Quartile	All	0.604	0.899	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

AFF1–LUAD (OS)

Open the LUAD breakdown →