AFF1

Across TCGA pan-cancer cohorts, AFF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AFF1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AFF1 RNA is repressed in tumor relative to normal tissue. In most cancer types AFF1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and LUSC are the cancer types where AFF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AFF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.928	<.001	7	view →
KICH	All	All	−0.919	<.001	7	view →
LUSC	Male	All	−0.614	<.001	6	view →
BRCA	Female	All	−0.361	<.001	6	view →
BLCA	Male	All	−0.721	.023	5	view →
LUAD	Female	All	−0.342	.030	3	view →
CHOL	All	All	+1.106	.001	2	view →
READ	All	All	−0.987	.005	2	view →
UCEC	All	All	−0.911	.001	2	view →
KIRP	Male	All	−0.725	<.001	2	view →
PRAD	All	All	+0.333	.010	2	view →
LIHC	Female	II,III,IV	+0.591	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

AFF1–COAD

Open the COAD breakdown →