AFF1

Across TCGA patient cohorts, AFF1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,434 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible AFF1-associated genes across cancer lineages are ATP1B3-AS1, DST, and PLPPR4. Each is linked with AFF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFF1-to-partner and partner-to-AFF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AFF1 versus ATP1B3-AS1 in COAD, with a Pearson correlation of -0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF1→partner) and Y-score (partner→AFF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATP1B3-AS1 →	-0.857	-0.916	.001	.009	3	3
UCEC	DST →	-0.705	-0.207	.002	.003	3	3
GBM	PLPPR4 →	-0.931	-0.348	<.001	.005	3	3
PDAC	ZNF365 →	-0.634	-0.323	.002	.001	3	3
CCRCC	ADAM12 →	-1.054	-0.286	<.001	.003	3	3
LSCC	MAP1A →	-0.721	-0.200	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,434 associations by consensus.

AFF1 vs ATP1B3-AS1 — COAD

Explore this scatter interactively →