AFF1

Across TCGA patient cohorts, AFF1 mutation is significantly associated with the RNA expression of many other genes, with 5,243 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFF1-associated genes across cancer lineages are MIR3908, NF2, and RN7SL478P. Each is linked with AFF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFF1-to-partner and partner-to-AFF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3908 grouped by AFF1-low versus AFF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF1→partner) and Y-score (partner→AFF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3908 →	+0.157	+4.734	<.001	.002	3	3
UCEC	NF2 →	+0.496	+1.760	<.001	<.001	3	3
LIHC	RN7SL478P →	+0.171	+5.413	.001	<.001	3	2
LIHC	MIR597 →	+0.383	+5.305	<.001	.003	3	2
PRAD	TRAPPC2P3 →	+0.129	+7.939	<.001	.008	3	2
LUAD	RPL30P5 →	+0.130	+3.656	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,243 associations by consensus.

MIR3908 by AFF1 expression — COAD

Explore this box plot interactively →