AFF1

Across TCGA patient cohorts, AFF1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFF1-associated genes across cancer lineages are GAPDH, Smad3, and ATM. Each is linked with AFF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFF1-to-partner and partner-to-AFF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by AFF1-low versus AFF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF1→partner) and Y-score (partner→AFF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.428	+3.169	.004	<.001	3	3
UCEC	Smad3 →	+0.108	+1.459	.010	.011	3	3
UCEC	ATM →	-0.527	-1.830	<.001	<.001	3	3
UCEC	Bak →	+0.179	+1.584	.011	.015	3	3
BLCA	PCNA →	+0.212	+3.000	.046	.036	3	2
UCEC	MEK1 →	+0.344	+2.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

GAPDH by AFF1 expression — UCEC

Explore this box plot interactively →