AFF1

Across TCGA cell cohorts, AFF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,111 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AFF1-associated GO terms across cancer lineages are Endosomal transport, Cellular response to nerve growth factor stimulus, and Negative regulation of organelle assembly. Each is linked with AFF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both AFF1-to-partner and partner-to-AFF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by AFF1-low versus AFF1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF1→partner) and Y-score (partner→AFF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.063	+1.180	.001	<.001	3	13
LARGE_INTESTINE	Cellular response to nerve growth factor stimulus →	+0.098	+0.968	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of organelle assembly →	+0.063	+0.873	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Response to insulin →	+0.056	+0.879	.002	.004	2	12
SOFT_TISSUE	Endocytic recycling →	+0.072	+1.319	<.001	<.001	3	11
OVARY	Positive regulation of GTPase activity →	+0.066	+1.330	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,111 associations by consensus.

Endosomal transport by AFF1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →