AFF1

Across TCGA cell cohorts, AFF1 mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFF1-associated genes across cancer lineages are VWA5B1, OR51I1, and FAM47A. Each is linked with AFF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFF1-to-partner and partner-to-AFF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWA5B1 grouped by AFF1-low versus AFF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF1→partner) and Y-score (partner→AFF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	VWA5B1 →	+0.899	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR51I1 →	+0.454	+4.093	<.001	.004	3	1
LUNG_NSCLC_LUAD	FAM47A →	+0.062	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR51I2 →	+0.246	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.065	+4.472	<.001	.001	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.104	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

VWA5B1 by AFF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →