AFDN

Across TCGA pan-cancer cohorts, AFDN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AFDN data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AFDN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AFDN expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, CCRCC, and OV are the cancer types where AFDN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	1.000	0.789	.004	20	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	10	view →
OV	DFS	Median	All	0.655	0.880	.047	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
HNSC	DFS	Median	II,III,IV	0.973	0.898	.031	3	view →
LUAD	OS	Quartile	III,IV	0.931	0.381	.039	2	view →
GBM	DFS	Tertile	All	0.800	0.687	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AFDN–UCEC (DFS)

Open the UCEC breakdown →