AFDN

Across TCGA pan-cancer cohorts, AFDN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of AFDN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AFDN RNA is repressed in tumor relative to normal tissue. In most cancer types AFDN is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and KIRC are the cancer types where AFDN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AFDN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.088	<.001	8	view →
LUSC	All	II,III,IV	−0.769	<.001	6	view →
KIRC	All	II,III,IV	−0.376	.003	6	view →
HNSC	All	II,III,IV	−0.520	.004	4	view →
LUAD	All	All	−0.406	.003	4	view →
BRCA	Female	All	−0.313	.003	4	view →
CHOL	All	All	+1.548	<.001	3	view →
LIHC	Female	III,IV	+0.830	.025	2	view →
PRAD	All	All	+0.534	<.001	2	view →
STAD	All	All	+0.595	.046	1	view →
KIRP	Male	All	−0.338	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

AFDN–KICH

Open the KICH breakdown →