AFDN

Across TCGA patient cohorts, AFDN RNA expression is significantly associated with the protein abundance of many other proteins, with 13,638 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AFDN-associated proteins across cancer lineages are MYO6, AFDN_S1182, and AFDN_S1275. Each is linked with AFDN in more than 5 cancer types. Because this analysis shows association rather than direction, both AFDN-to-partner and partner-to-AFDN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AFDN versus MYO6 in UCEC, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AFDN→partner) and Y-score (partner→AFDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO6 →	+0.437	+0.451	.001	.006	3	6
BRCA	AFDN_S1182 →	+0.714	+0.923	<.001	<.001	3	6
BRCA	AFDN_S1275 →	+0.770	+0.680	<.001	<.001	3	6
PDAC	AFDN_S1107 →	+0.353	+0.355	.005	.002	3	6
GBM	AFDN_S246 →	+0.643	+0.852	<.001	<.001	3	6
LSCC	DNAJC1 →	-0.387	-0.377	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,638 associations by consensus.

AFDN vs MYO6 — UCEC

Explore this scatter interactively →