AFDN

Across TCGA patient cohorts, AFDN mutation is significantly associated with the RNA expression of many other genes, with 6,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFDN-associated genes across cancer lineages are XPNPEP1, PKN3, and LETM1. Each is linked with AFDN in more than 4 cancer types. Because this analysis shows association rather than direction, both AFDN-to-partner and partner-to-AFDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XPNPEP1 grouped by AFDN-low versus AFDN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFDN→partner) and Y-score (partner→AFDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	XPNPEP1 →	+0.435	+3.512	<.001	.002	3	5
UCEC	PKN3 →	+0.846	+2.568	<.001	<.001	3	5
UCEC	LETM1 →	+0.471	+1.820	<.001	<.001	3	5
LUSC	MINDY4 →	-0.245	-2.682	.005	.006	3	5
SKCM	TRAF3IP2 →	+0.559	+2.710	.008	.003	3	5
COAD	F10 →	-1.051	-2.321	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,576 associations by consensus.

XPNPEP1 by AFDN expression — COAD

Explore this box plot interactively →