AFDN

Across TCGA cell cohorts, AFDN mutation is significantly associated with the RNA expression of many other genes, with 1,627 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFDN-associated genes across cancer lineages are L3MBTL2, CTSZ, and USP31. Each is linked with AFDN in more than 1 cancer types. Because this analysis shows association rather than direction, both AFDN-to-partner and partner-to-AFDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L3MBTL2 grouped by AFDN-low versus AFDN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFDN→partner) and Y-score (partner→AFDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	L3MBTL2 →	+0.640	+2.115	<.001	.001	3	2
BLOOD_Leukemia	CTSZ →	-2.215	-3.321	.002	.005	3	2
BLOOD_Leukemia	USP31 →	+0.510	+3.215	.002	.005	3	2
BLOOD_Leukemia	DHX15 →	+0.527	+2.614	.001	.003	3	2
BLOOD_Leukemia	TTK →	+0.718	+3.730	.002	<.001	3	2
BLOOD_Leukemia	TRIM62 →	+0.601	+3.214	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,627 associations by consensus.

L3MBTL2 by AFDN expression — LARGE_INTESTINE

Explore this box plot interactively →