AFAP1L1

Across TCGA patient cohorts, AFAP1L1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFAP1L1-associated genes across cancer lineages are Caspase-7-cleavedD198, TSC1, and GAPDH. Each is linked with AFAP1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFAP1L1-to-partner and partner-to-AFAP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AFAP1L1-low versus AFAP1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1L1→partner) and Y-score (partner→AFAP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.718	+1.523	<.001	.008	3	3
COAD	TSC1 →	-0.364	-3.161	.007	.019	3	2
UCEC	GAPDH →	+0.464	+2.415	.006	.002	3	2
UCEC	p62 Lck ligand →	+0.347	+1.857	<.001	.004	3	2
UCEC	PDCD4 →	-0.334	-3.459	.026	.005	3	2
UCEC	PI3K-p110-a →	-0.129	-1.847	.022	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by AFAP1L1 expression — UCEC

Explore this box plot interactively →