AFAP1L1

Across TCGA cell cohorts, AFAP1L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,187 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AFAP1L1-associated GO terms across cancer lineages are Positive regulation of cell-substrate adhesion, Regulation of fibroblast proliferation, and Regulation of cell-substrate adhesion. Each is linked with AFAP1L1 in more than 12 cancer types. Because this analysis shows association rather than direction, both AFAP1L1-to-partner and partner-to-AFAP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate adhesion grouped by AFAP1L1-low versus AFAP1L1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1L1→partner) and Y-score (partner→AFAP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-substrate adhesion →	+0.160	+2.225	<.001	<.001	3	13
BREAST	Regulation of fibroblast proliferation →	+0.126	+1.801	<.001	<.001	3	12
BONE	Regulation of cell-substrate adhesion →	+0.129	+1.783	<.001	<.001	3	11
BONE	Positive regulation of cell-matrix adhesion →	+0.167	+1.781	<.001	<.001	3	11
BONE	Viral process →	+0.110	+2.654	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of fibroblast proliferation →	+0.201	+2.107	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,187 associations by consensus.

Positive regulation of cell-substrate adhesion by AFAP1L1 expression — BONE

Explore this box plot interactively →