AFAP1L1

Across TCGA cell cohorts, AFAP1L1 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFAP1L1-associated genes across cancer lineages are SH3GL2, UHRF1BP1L, and SDHB. Each is linked with AFAP1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFAP1L1-to-partner and partner-to-AFAP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by AFAP1L1-low versus AFAP1L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1L1→partner) and Y-score (partner→AFAP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+0.960	+3.364	.006	.002	3	1
LARGE_INTESTINE	UHRF1BP1L →	+0.510	+3.364	.009	.002	3	1
LARGE_INTESTINE	SDHB →	+0.550	+3.451	.001	.002	3	1
LARGE_INTESTINE	PRDX1 →	+0.600	+3.169	.008	.009	3	1
LARGE_INTESTINE	PDS5A →	+0.576	+3.364	.003	.002	3	1
LARGE_INTESTINE	NQO2 →	+1.099	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

SH3GL2 by AFAP1L1 expression — LARGE_INTESTINE

Explore this box plot interactively →