AFAP1-AS1

Across TCGA pan-cancer cohorts, AFAP1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated AFAP1-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AFAP1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AFAP1-AS1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and LUSC show a favorable association.

COAD, KIRC, and THYM are the cancer types where AFAP1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.521	0.711	<.001	116	view →
KIRC	DFS	Median	All	0.752	0.851	<.001	68	view →
THYM	DFS	Median	All	0.588	0.910	<.001	62	view →
ACC	OS	Tertile	All	0.302	0.810	<.001	61	view →
KIRP	OS	Quartile	All	0.862	0.978	.001	55	view →
LIHC	DFS	Quartile	All	0.213	0.405	.006	36	view →
HNSC	OS	Median	All	0.275	0.483	.006	21	view →
CESC	DFS	Tertile	IV	0.105	0.581	.014	18	view →
SARC	OS	Tertile	All	0.403	0.792	<.001	16	view →
CHOL	DFS	Tertile	All	0.613	0.145	.004	15	view →
KICH	OS	Tertile	III,IV	0.301	1.000	.003	14	view →
OV	OS	Quartile	III,IV	0.601	0.722	.023	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

AFAP1-AS1–COAD (OS)

Open the COAD breakdown →