AFAP1-AS1

Across TCGA pan-cancer cohorts, AFAP1-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AFAP1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AFAP1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AFAP1-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUAD, and STAD are the cancer types where AFAP1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AFAP1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+2.161	<.001	12	view →
LUAD	Female	II,III,IV	+3.726	<.001	9	view →
STAD	All	III,IV	+3.228	.001	9	view →
KIRC	All	III,IV	+0.618	<.001	9	view →
COAD	All	II,III,IV	+1.231	<.001	8	view →
LIHC	All	All	+0.704	<.001	6	view →
LUSC	All	All	+1.252	<.001	5	view →
BRCA	All	II,III,IV	+0.608	<.001	4	view →
CHOL	All	All	+3.943	<.001	3	view →
READ	All	III,IV	+3.355	.001	2	view →
PAAD	All	All	+2.650	.046	2	view →
THCA	Male	All	+0.089	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

AFAP1-AS1–HNSC

Open the HNSC breakdown →