AEBP1

Across TCGA patient cohorts, AEBP1 mutation is significantly associated with the RNA expression of many other genes, with 4,126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AEBP1-associated genes across cancer lineages are GCH1, XYLB, and HASPIN. Each is linked with AEBP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AEBP1-to-partner and partner-to-AEBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCH1 grouped by AEBP1-low versus AEBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AEBP1→partner) and Y-score (partner→AEBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GCH1 →	+0.682	+2.401	<.001	<.001	3	4
UCEC	XYLB →	+0.449	+2.180	<.001	.001	3	4
UCEC	HASPIN →	+0.788	+2.099	<.001	<.001	3	4
UCEC	LIN52 →	+0.285	+2.849	.007	.001	3	4
LUAD	IPMK →	+0.391	+2.150	.003	.009	3	3
UCEC	CHAF1A →	+0.652	+2.390	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,126 associations by consensus.

GCH1 by AEBP1 expression — UCEC

Explore this box plot interactively →