ADRM1

Across TCGA patient cohorts, ADRM1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRM1-associated genes across cancer lineages are MSH6, N-Ras, and PDK1_pS241. Each is linked with ADRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRM1-to-partner and partner-to-ADRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by ADRM1-low versus ADRM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRM1→partner) and Y-score (partner→ADRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.563	-2.321	<.001	.035	3	1
UCEC	N-Ras →	-0.118	-2.308	.047	.036	3	1
UCEC	PDK1_pS241 →	+0.189	+2.335	.028	.020	3	1
UCEC	Rad50 →	-0.294	-2.321	.015	.035	3	1
UCEC	Shc_pY317 →	-0.169	-3.169	.026	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+1.169	+2.189	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MSH6 by ADRM1 expression — UCEC

Explore this box plot interactively →