ADRB1

Across TCGA patient cohorts, ADRB1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRB1-associated genes across cancer lineages are ERK2, GSK3-a-b, and JNK2. Each is linked with ADRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRB1-to-partner and partner-to-ADRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ADRB1-low versus ADRB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRB1→partner) and Y-score (partner→ADRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.182	+1.700	.026	.044	3	1
UCEC	GSK3-a-b →	+0.114	+2.222	.047	.011	3	1
UCEC	JNK2 →	+0.245	+3.009	.003	.019	3	1
UCEC	Ku80 →	+0.304	+2.235	.002	.006	3	1
UCEC	MEK1 →	+0.347	+2.584	.025	.010	3	1
UCEC	Notch1 →	+0.180	+3.594	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ERK2 by ADRB1 expression — UCEC

Explore this box plot interactively →