ADRB1

Across TCGA cell cohorts, ADRB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,063 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADRB1-associated GO terms across cancer lineages are Positive regulation of blood pressure by epinephrine-norepinephrine, Regulation of systemic arterial blood pressure by norepinephrine-epinephrine, and Adenylate cyclase-activating adrenergic receptor signaling pathway. Each is linked with ADRB1 in more than 13 cancer types. Because this analysis shows association rather than direction, both ADRB1-to-partner and partner-to-ADRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of blood pressure by epinephrine-norepinephrine grouped by ADRB1-low versus ADRB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRB1→partner) and Y-score (partner→ADRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of blood pressure by epinephrine-norepinephrine →	-0.655	-2.972	<.001	<.001	3	14
BONE	Regulation of systemic arterial blood pressure by norepinephrine-epinephrine →	-0.576	-3.042	<.001	<.001	3	9
BLOOD_Leukemia	Adenylate cyclase-activating adrenergic receptor signaling pathway →	-0.235	-0.882	<.001	<.001	3	7
BREAST	Negative regulation of systemic arterial blood pressure →	-0.216	-0.597	<.001	.001	1	8
SKIN	Formation of cytoplasmic translation initiation complex →	+0.067	+0.203	<.001	<.001	3	6
BONE	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure →	+1.567	+2.857	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,063 associations by consensus.

Positive regulation of blood pressure by epinephrine-norepinephrine by ADRB1 expression — BONE

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