Across TCGA patient cohorts, ADRA2C mutation is significantly associated with the RNA expression of many other genes, with 524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRA2C-associated genes across cancer lineages are RN7SKP162, RNA5SP84, and RN7SKP59. Each is linked with ADRA2C in more than 2 cancer types. Because this analysis shows association rather than direction, both ADRA2C-to-partner and partner-to-ADRA2C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2C→partner) and Y-score (partner→ADRA2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SKP162 →	+0.126	+5.357	<.001	.001	3	3
HNSC	RNA5SP84 →	+0.224	+4.608	<.001	.005	3	2
UCEC	RN7SKP59 →	+0.070	+2.835	.007	.003	3	2
STAD	EEF1E1-BLOC1S5 →	+0.040	+5.026	.006	.009	3	2
UCEC	HNMT →	-0.757	-3.568	.004	.002	3	1
UCEC	CCDC3 →	-0.817	-2.807	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 524 associations by consensus.

Exploration

ADRA2C survival (RNA) · tumor vs normal (RNA) · all ADRA2C data types