Across TCGA patient cohorts, ADRA2C mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRA2C-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and A-Raf_pS299. Each is linked with ADRA2C in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA2C-to-partner and partner-to-ADRA2C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2C→partner) and Y-score (partner→ADRA2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.123	-3.143	.008	.018	3	1
UCEC	eIF4E →	+0.217	+2.321	.027	.034	3	1
UCEC	A-Raf_pS299 →	-0.233	-3.321	<.001	.010	3	1
UCEC	ERK2 →	+0.302	+3.459	<.001	.005	3	1
UCEC	FoxM1 →	+0.249	+2.584	.039	.011	3	1
UCEC	GATA6 →	-0.234	-3.307	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

ADRA2C survival (RNA) · tumor vs normal (RNA) · all ADRA2C data types