Across TCGA cell cohorts, ADRA2C mutation is significantly associated with the RNA expression of many other genes, with 513 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADRA2C-associated genes across cancer lineages are RBMY1B, GCAT, and CBY1. Each is linked with ADRA2C in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA2C-to-partner and partner-to-ADRA2C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2C→partner) and Y-score (partner→ADRA2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RBMY1B →	+1.113	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GCAT →	+1.270	+3.743	<.001	<.001	3	1
LARGE_INTESTINE	CBY1 →	+0.589	+2.714	<.001	.002	3	1
LARGE_INTESTINE	SLC25A17 →	+0.624	+2.628	<.001	.002	3	1
LARGE_INTESTINE	ST13 →	+0.538	+3.459	.001	.001	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.606	+2.628	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 513 associations by consensus.

Exploration

ADRA2C survival (RNA) · tumor vs normal (RNA) · all ADRA2C data types