ADRA1B

Across TCGA cell cohorts, ADRA1B mutation is significantly associated with the RNA expression of many other genes, with 292 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADRA1B-associated genes across cancer lineages are AQP8, CCR8, and C16orf90. Each is linked with ADRA1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA1B-to-partner and partner-to-ADRA1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP8 grouped by ADRA1B-low versus ADRA1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA1B→partner) and Y-score (partner→ADRA1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AQP8 →	+0.080	+3.474	.002	.007	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
BLOOD_Myeloma	PIP →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP19-3 →	+0.236	+4.807	<.001	.006	3	1
SKIN	P2RY13 →	+0.005	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 292 associations by consensus.

AQP8 by ADRA1B expression — BLOOD_Leukemia

Explore this box plot interactively →