ADRA1B

Across TCGA pan-cancer cohorts, ADRA1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADRA1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADRA1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADRA1B is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where ADRA1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADRA1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+1.685	<.001	12	view →
KICH	Male	All	−1.884	<.001	11	view →
COAD	Female	III,IV	−1.066	<.001	11	view →
THCA	Male	III,IV	+1.484	<.001	9	view →
LIHC	All	II,III,IV	−1.096	<.001	8	view →
LUSC	Female	II,III,IV	−2.174	<.001	7	view →
HNSC	Female	IV	+0.966	<.001	7	view →
UCEC	All	All	−1.444	<.001	6	view →
BRCA	All	III,IV	−0.829	<.001	6	view →
LUAD	Female	All	−0.651	<.001	4	view →
CHOL	All	All	−1.523	<.001	3	view →
PRAD	All	All	−0.713	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADRA1B–KIRC

Open the KIRC breakdown →