ADRA1A

Across TCGA patient cohorts, ADRA1A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRA1A-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and TTF1. Each is linked with ADRA1A in more than 2 cancer types. Because this analysis shows association rather than direction, both ADRA1A-to-partner and partner-to-ADRA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADRA1A-low versus ADRA1A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA1A→partner) and Y-score (partner→ADRA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.172	+2.824	.002	.034	3	3
LUSC	MEK1 →	-0.307	-3.160	.001	.019	3	2
SKCM	TTF1 →	+0.179	+2.848	.033	.032	3	2
UCEC	Cyclin-B1 →	+0.530	+2.222	.004	.009	3	2
UCEC	JNK2 →	+0.226	+2.331	<.001	.003	3	2
UCEC	Ku80 →	+0.213	+1.665	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by ADRA1A expression — COAD

Explore this box plot interactively →