ADPRH

Across TCGA patient cohorts, ADPRH mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADPRH-associated genes across cancer lineages are ATM, INPP4B, and mTOR_pS2448. Each is linked with ADPRH in more than 1 cancer types. Because this analysis shows association rather than direction, both ADPRH-to-partner and partner-to-ADPRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADPRH-low versus ADPRH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADPRH→partner) and Y-score (partner→ADPRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.791	-3.156	<.001	.018	3	2
UCEC	INPP4B →	-0.431	-3.321	.004	.010	2	2
UCEC	mTOR_pS2448 →	-0.171	-2.986	.013	.035	3	1
UCEC	Notch1 →	+0.179	+3.013	.006	.018	3	1
UCEC	p62 Lck ligand →	+0.357	+2.817	.018	.036	3	1
UCEC	PDCD4 →	-0.620	-3.160	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by ADPRH expression — UCEC

Explore this box plot interactively →