ADPRH

Across TCGA pan-cancer cohorts, ADPRH RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ADPRH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ADPRH RNA is repressed in tumor relative to normal tissue. In most cancer types ADPRH is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where ADPRH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADPRH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.911	<.001	11	view →
THCA	All	IV	−1.282	<.001	10	view →
KIRC	Female	All	+0.823	<.001	10	view →
LUAD	Female	III,IV	−1.676	<.001	9	view →
LUSC	Female	II,III,IV	−2.088	<.001	8	view →
BRCA	All	III,IV	−0.736	<.001	6	view →
HNSC	All	III,IV	+0.538	.004	6	view →
BLCA	Male	III,IV	−1.057	.002	4	view →
LIHC	Female	All	+0.642	<.001	4	view →
CHOL	All	All	+1.506	<.001	3	view →
PAAD	All	All	−1.382	.015	2	view →
UCEC	All	All	−1.314	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ADPRH–KICH

Open the KICH breakdown →