ADORA2A

Across TCGA patient cohorts, ADORA2A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADORA2A-associated genes across cancer lineages are MSH2, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with ADORA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADORA2A-to-partner and partner-to-ADORA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ADORA2A-low versus ADORA2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADORA2A→partner) and Y-score (partner→ADORA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.188	-2.433	.018	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.791	+2.604	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.078	-1.973	.025	.029	3	1
UCEC	eEF2 →	+0.310	+2.000	.012	.029	3	1
UCEC	EGFR_pY1068 →	-0.270	-2.070	.001	.001	3	1
UCEC	eIF4E →	+0.161	+2.335	.027	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MSH2 by ADORA2A expression — UCEC

Explore this box plot interactively →