ADORA2A

Across TCGA pan-cancer cohorts, ADORA2A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated ADORA2A data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADORA2A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ADORA2A expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ACC are the cancer types where ADORA2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.417	0.235	<.001	137	view →
SKCM	OS	Tertile	All	0.460	0.273	<.001	76	view →
ACC	DFS	Quartile	All	0.165	0.600	<.001	68	view →
LUSC	DFS	Tertile	II,III,IV	0.287	0.491	.002	58	view →
KIRC	DFS	Median	All	0.874	0.709	<.001	45	view →
PAAD	OS	Median	All	0.478	0.314	.006	35	view →
UCS	OS	Tertile	IV	0.938	0.405	.024	26	view →
LUAD	OS	Tertile	II,III,IV	0.768	0.466	.004	24	view →
THYM	OS	Median	All	1.000	0.738	.001	22	view →
PRAD	DFS	Quartile	All	0.629	0.866	.005	16	view →
BLCA	OS	Tertile	IV	0.735	0.524	.016	13	view →
THCA	OS	Tertile	II,III,IV	0.910	0.978	.027	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

ADORA2A–HNSC (DFS)

Open the HNSC breakdown →