ADORA2A

Across TCGA cell cohorts, ADORA2A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,885 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADORA2A-associated GO terms across cancer lineages are Positive regulation of acetylcholine secretion, neurotransmission, Positive regulation of circadian sleep/wake cycle, sleep, and Regulation of acetylcholine secretion, neurotransmission. Each is linked with ADORA2A in more than 16 cancer types. Because this analysis shows association rather than direction, both ADORA2A-to-partner and partner-to-ADORA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of acetylcholine secretion, neurotransmission grouped by ADORA2A-low versus ADORA2A-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADORA2A→partner) and Y-score (partner→ADORA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of acetylcholine secretion, neurotransmission →	+1.636	+3.630	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Positive regulation of circadian sleep/wake cycle, sleep →	+1.753	+2.952	<.001	<.001	3	17
BLOOD_Lymphoma	Regulation of acetylcholine secretion, neurotransmission →	+1.762	+3.647	<.001	<.001	3	16
PANCREAS	Positive regulation of synaptic transmission, cholinergic →	-0.295	-1.398	<.001	<.001	3	14
OESOPHAGUS	Symbiont-mediated disruption of host cellular anatomical structure →	+0.126	+1.109	.002	.004	3	11
OESOPHAGUS	Symbiont-mediated disruption of host anatomical structure →	+0.126	+1.109	.002	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,885 associations by consensus.

Positive regulation of acetylcholine secretion, neurotransmission by ADORA2A expression — BLOOD_Lymphoma

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