ADORA2A

Across TCGA cell cohorts, ADORA2A mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADORA2A-associated genes across cancer lineages are PCDH11Y and OCM2. Each is linked with ADORA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADORA2A-to-partner and partner-to-ADORA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11Y grouped by ADORA2A-low versus ADORA2A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADORA2A→partner) and Y-score (partner→ADORA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
LARGE_INTESTINE	OCM2 →	+0.082	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PCDH11Y by ADORA2A expression — URINARY_TRACT

Explore this box plot interactively →