ADO

Across TCGA patient cohorts, ADO mutation is significantly associated with the RNA expression of many other genes, with 1,476 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADO-associated genes across cancer lineages are RN7SL714P, SF3B4P1, and MRPL49. Each is linked with ADO in more than 1 cancer types. Because this analysis shows association rather than direction, both ADO-to-partner and partner-to-ADO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL714P grouped by ADO-low versus ADO-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADO→partner) and Y-score (partner→ADO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL714P →	+0.219	+4.557	.003	.004	3	2
COAD	SF3B4P1 →	+0.233	+3.947	<.001	.001	3	2
UCEC	MRPL49 →	+0.430	+2.700	.007	.005	3	2
UCEC	UBASH3B →	+0.545	+2.423	.003	.001	3	2
UCEC	MIS18A →	+0.616	+2.736	<.001	<.001	3	2
UCEC	CHAF1B →	+0.699	+4.016	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,476 associations by consensus.

RN7SL714P by ADO expression — COAD

Explore this box plot interactively →