ADNP

Across TCGA pan-cancer cohorts, ADNP Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ADNP data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ADNP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ADNP expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

BRCA, COAD, and READ are the cancer types where ADNP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	II,III,IV	0.313	0.913	<.001	26	view →
COAD	OS	Median	III,IV	0.056	0.793	<.001	18	view →
READ	OS	Median	III,IV	0.644	0.932	<.001	16	view →
UCEC	DFS	Median	All	0.949	0.614	.006	10	view →
ACC	DFS	Median	All	0.210	0.766	<.001	9	view →
LIHC	DFS	Median	All	0.143	0.546	.002	6	view →
SKCM	OS	Median	II,III,IV	1.000	0.304	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ADNP–BRCA (OS)

Open the BRCA breakdown →