ADNP

Across TCGA pan-cancer cohorts, ADNP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ADNP data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADNP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ADNP expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where ADNP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.799	1.000	<.001	44	view →
PDAC	OS	Quartile	II,III,IV	0.363	0.583	.036	6	view →
CCRCC	OS	Tertile	All	0.883	1.000	.010	6	view →
GBM	OS	Quartile	All	0.568	0.288	.015	4	view →
LSCC	DFS	Tertile	All	0.959	0.886	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ADNP–HNSC (OS)

Open the HNSC breakdown →